Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man
S Dragovic, NPE Vermeulen, HH Gerets, PG Hewitt… - Archives of …, 2016 - Springer
The current test systems employed by pharmaceutical industry are poorly predictive for drug-
induced liver injury (DILI). The 'MIP-DILI'project addresses this situation by the development …
induced liver injury (DILI). The 'MIP-DILI'project addresses this situation by the development …
A review of drug‐induced lysosomal disorders of the liver in man and laboratory animals
P Schneider, TA Korolenko… - Microscopy research and …, 1997 - Wiley Online Library
Lysosomotropic agents are selectively taken up into lysosomes following their administration
to man and animals [de Duve et al.(1974) Biochem. Pharmacol. 23: 2494–2531] The effects …
to man and animals [de Duve et al.(1974) Biochem. Pharmacol. 23: 2494–2531] The effects …
Amiodarone‐Induced Cirrhosis of Liver: What Predicts Mortality?
N Hussain, A Bhattacharyya… - International Scholarly …, 2013 - Wiley Online Library
Introduction. Amiodarone has been used for more than 5 decades for the treatment of
various tachyarrhythmias and previously for the treatment of refractory angina. There are …
various tachyarrhythmias and previously for the treatment of refractory angina. There are …
Granular cells as a marker of early amiodarone hepatotoxicity: a pathological and analytical study.
NA Shepherd, AM Dawson, PR Crocker… - Journal of clinical …, 1987 - jcp.bmj.com
Two contrasting cases of amiodarone hepatotoxicity are described. In one, perivenular
collections of swollen cells, probably macrophages, with granular cytoplasm in an otherwise …
collections of swollen cells, probably macrophages, with granular cytoplasm in an otherwise …
Hepatotoxicity of cardiovascular and antidiabetic drugs
FA de la Iglesia, JR Haskins… - Drug-Induced liver …, 2003 - api.taylorfrancis.com
Cardiovascular disease and diabetes are among the leading causes of mortality and
morbidity in the civilized world. Therapeutic approaches to these diseases in general require …
morbidity in the civilized world. Therapeutic approaches to these diseases in general require …
[PDF][PDF] 28 Hepatotoxicity of Cardiovascular and Antidiabetic Medications
SS Bhardwaj, NP Chalasani - Drug-Induced Liver Disease, 2007 - repo.upertis.ac.id
Drugs used in the treatment of cardiovascular disorders and diabetes are among the most
commonly prescribed medications in the United States. Figures 1 and 2 show a …
commonly prescribed medications in the United States. Figures 1 and 2 show a …