The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

A fundamental question in bone biology concerns the contributions of skeletal
stem/progenitor cells (SSCs) in the bone marrow versus the periosteum to bone repair. We …

The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This
process is thought to impair osteogenic and hematopoietic regeneration. Here we specify …

Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain
poorly characterized. Here, we show that periosteum contains SSCs with high bone …