Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

DE Johnson, RA O'Keefe, JR Grandis - Nature reviews Clinical …, 2018 - nature.com
Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

Cytokine storm and sepsis disease pathogenesis

BG Chousterman, FK Swirski, GF Weber - Seminars in immunopathology, 2017 - Springer
Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical
syndrome related to the host response to infection. The severity of infections is due to an …

Role of interleukin-6 in cancer progression and therapeutic resistance

N Kumari, BS Dwarakanath, A Das, AN Bhatt - Tumor Biology, 2016 - Springer
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

IL-6 as a keystone cytokine in health and disease

CA Hunter, SA Jones - Nature immunology, 2015 - nature.com
Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

F Mirabella, G Desiato, S Mancinelli, G Fossati… - Immunity, 2021 - cell.com
Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …

What does plasma CRP tell us about peripheral and central inflammation in depression?

JC Felger, E Haroon, TA Patel, DR Goldsmith… - Molecular …, 2020 - nature.com
Peripheral blood C-reactive protein (CRP) is a biomarker used clinically to measure
systemic inflammation and is reproducibly increased in a subset of patients with major …

Inflammation and inflammatory cytokine contribute to the initiation and development of ulcerative colitis and its associated cancer

D Yao, M Dong, C Dai, S Wu - Inflammatory bowel diseases, 2019 - academic.oup.com
Dysregulated inflammatory responses play a pivotal role in the initiation, development, and
progression of tumors, as demonstrated by the association between ulcerative colitis and the …

The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology

JE Millar, JP Fanning, CI McDonald, DF McAuley… - Critical care, 2016 - Springer
Extracorporeal membrane oxygenation (ECMO) is a technology capable of providing short-
term mechanical support to the heart, lungs or both. Over the last decade, the number of …

Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?

K Rehman, MSH Akash - Journal of biomedical science, 2016 - Springer
Background Insulin resistance (IR) is one of the major hallmark for pathogenesis and
etiology of type 2 diabetes mellitus (T2DM). IR is directly interlinked with various …