Anti-inflammatory action of statins in cardiovascular disease: the role of inflammasome and toll-like receptor pathways
K Koushki, SK Shahbaz, K Mashayekhi… - Clinical reviews in …, 2021 - Springer
Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …
Sleep health: reciprocal regulation of sleep and innate immunity
Sleep disturbances including insomnia independently contribute to risk of inflammatory
disorders and major depressive disorder. This review and overview provides an integrated …
disorders and major depressive disorder. This review and overview provides an integrated …
Why sleep is important for health: a psychoneuroimmunology perspective
MR Irwin - Annual review of psychology, 2015 - annualreviews.org
Sleep has a critical role in promoting health. Research over the past decade has
documented that sleep disturbance has a powerful influence on the risk of infectious …
documented that sleep disturbance has a powerful influence on the risk of infectious …
The many facets of macrophages in rheumatoid arthritis
E Siouti, E Andreakos - Biochemical pharmacology, 2019 - Elsevier
Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …
Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage
R Virmani, FD Kolodgie, AP Burke, AV Finn… - … , and vascular biology, 2005 - Am Heart Assoc
Observational studies of necrotic core progression identify intraplaque hemorrhage as a
critical factor in atherosclerotic plaque growth and destabilization. The rapid accumulation of …
critical factor in atherosclerotic plaque growth and destabilization. The rapid accumulation of …
Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation
MR Irwin, M Wang, CO Campomayor… - Archives of internal …, 2006 - jamanetwork.com
Background Inflammation is associated with increased risk of cardiovascular disorders,
arthritis, diabetes mellitus, and mortality. The effects of sleep loss on the cellular and …
arthritis, diabetes mellitus, and mortality. The effects of sleep loss on the cellular and …
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
FJ Barrat, T Meeker, J Gregorio, JH Chan… - The Journal of …, 2005 - rupress.org
Raised serum levels of interferon (IFN)-α have been observed in systemic lupus
erythematosus (SLE) patients, and these levels are correlated with both disease activity and …
erythematosus (SLE) patients, and these levels are correlated with both disease activity and …
The effect of insomnia on development of Alzheimer's disease
Alzheimer's disease (AD) is the most common type of dementia and a neurodegenerative
disorder characterized by memory deficits especially forgetting recent information, recall …
disorder characterized by memory deficits especially forgetting recent information, recall …
Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late-life insomnia: a randomized controlled trial
MR Irwin, R Olmstead, EC Breen, T Witarama… - Biological …, 2015 - Elsevier
Background Sleep disturbance is associated with activation of systemic and cellular
inflammation, as well as proinflammatory transcriptional profiles in circulating leukocytes …
inflammation, as well as proinflammatory transcriptional profiles in circulating leukocytes …
Effect of statins on toll-like receptors: a new insight to pleiotropic effects
The toll-like receptors (TLRs) are a class of transmembrane-spanning receptors that are
sentinels of both innate and adaptive immunity. Statins (3-hydroxy-3-methylglutaryl …
sentinels of both innate and adaptive immunity. Statins (3-hydroxy-3-methylglutaryl …