BACKGROUND Numerous studies have reported declines in semen quality and other
markers of male reproductive health. Our previous meta-analysis reported a significant …

BACKGROUND Reported declines in sperm counts remain controversial today and recent
trends are unknown. A definitive meta-analysis is critical given the predictive value of sperm …

Abstract Approximately 10%–15% of couples are infertile, and a male factor is involved in
almost half of these cases. This observation is due in part to defects in spermatogenesis …

It has been demonstrated that human exposure to environmental chemicals may have
sperm genotoxic potentiality. Among the different classes, Polycyclic Aromatic Hydrocarbons …

Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

The male reproductive system is acutely and uniquely sensitive to a variety of toxicities,
including those induced by environmental pollutants throughout the lifespan. Early life …

Introduction Infertility is a major health problem, worldwide, which affects 10–15% of
couples. About half a percent of infertility cases are related to male-related factors. Male …

In this chapter, we review the male reproductive functions disrupted by medications.
Medications can affect the hypothalamic–pituitary–gonad axis, acting as endocrine …

The study was designed to investigate the associations of polymorphisms Ile462Val and
3801T> C of the cytochrome P450 1A1 (CYP1A1) gene with idiopathic male infertility (IMI) …

The human cytochrome P450 1A (CYP1A) subfamily genes, CYP1A1 and CYP1A2,
encoding monooxygenases are critically involved in biotransformation of key endogenous …