DNA adduct formation from tobacco-specific N-nitrosamines
SS Hecht - … Research/Fundamental and Molecular Mechanisms of …, 1999 - Elsevier
Tobacco-specific N-nitrosamines are a group of carcinogens derived from the tobacco
alkaloids. They are likely causative factors for cancers of the lung, esophagus, pancreas …
alkaloids. They are likely causative factors for cancers of the lung, esophagus, pancreas …
Oral spit tobacco: addiction, prevention and treatment
DK Hatsukami, HH Severson - Nicotine & Tobacco Research, 1999 - academic.oup.com
The prevalence of smokeless tobacco is significant and reaches as high as 17% past month
use in white males aged 18–25. Smokeless tobacco use is of concern because of the …
use in white males aged 18–25. Smokeless tobacco use is of concern because of the …
Comparative Tumorigenicity and DNA Methylation in F344 Rats by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-Nitrosodimethylamine
SS Hecht, N Trushin, A Castonguay, A Rivenson - Cancer Research, 1986 - AACR
The tumorigenic activities and DNA methylating abilities in F344 rats of the tobacco specific
nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the structurally …
nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the structurally …
[HTML][HTML] Health consequences of using smokeless tobacco: summary of the Advisory Committee's report to the Surgeon General.
JW Cullen, W Blot, J Henningfield, G Boyd… - Public health …, 1986 - ncbi.nlm.nih.gov
Abstract On March 25, 1986, the Surgeon General of the Public Health Service released a
report that detailed the results of the first comprehensive, indepth review of the relationship …
report that detailed the results of the first comprehensive, indepth review of the relationship …
Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen
SS Hecht - Tobacco-Specific N-Nitrosamines Recent …, 2017 - api.taylorfrancis.com
This article reviews recent advances in the biochemistry and molecular biology of 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific pulmonary car …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific pulmonary car …
Accumulation and Persistence of DNA Adducts in Respiratory Tissue of Rats following Multiple Administrations of the Tobacco Specific Carcinogen 4-(N-Methyl-N …
SA Belinsky, CM White, JA Boucheron, FC Richardson… - Cancer Research, 1986 - AACR
(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a major nitrosamine formed in
tobacco smoke, induces a high incidence of lung, liver, and nasal cavity tumors in rats. Since …
tobacco smoke, induces a high incidence of lung, liver, and nasal cavity tumors in rats. Since …
Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone α-hydroxylation and DNA methylation in …
FL Chung, M Wang, SS Hecht - Carcinogenesis, 1985 - academic.oup.com
Dietary-related indoles, isothiocyanates, and the allkyl isothiocyanate glucosinolate, sinigrin,
were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h …
were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h …
Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in …
JF Cloutier, R Drouin, M Weinfeld, TR O'Connor… - Journal of Molecular …, 2001 - Elsevier
The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an important
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …
[PDF][PDF] IARC monographs on the evaluation of carcinogenic risks to humans
F Lyon - … organization, International agency for research on …, 2014 - monographs.iarc.who.int
An IARC Advisory Group to Recommend Priorities for IARC Monographs during 2015–2019
met in Lyon, France, on 7–9 April 2014. Before the meeting, IARC solicited nominations of …
met in Lyon, France, on 7–9 April 2014. Before the meeting, IARC solicited nominations of …
Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice
LM Anderson, SS Hecht, DE Dixon, LF Dove… - Cancer research, 1989 - AACR
The transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) was assessed in three strains of mice: A/J; C3H/He× …
1-(3-pyridyl)-1-butanone (NNK) was assessed in three strains of mice: A/J; C3H/He× …