The field of microbial cooperation has grown enormously over the last decade, leading to
improved experimental techniques and a growing awareness of collective behavior in …

Endogenous bioelectric patterns within tissues are an important driver of morphogenesis
and a tractable component of a number of disease states. Developing system-level …

The periodic segmentation of the vertebrate body axis into somites, and later vertebrae,
relies on a genetic oscillator (the segmentation clock) driving the rhythmic activity of …

Introduction Cells that simultaneously secrete and sense the same signaling molecule are
ubiquitous. Bacteria sense a quorum by secreting and sensing an autoinducer; T cells …

Understanding how biochemical networks lead to large-scale nonequilibrium self-
organization and pattern formation in life is a major challenge, with important implications for …

Tissue development occurs through a complex interplay between many individual cells. Yet,
the fundamental question of how collective tissue behavior emerges from heterogeneous …

A rigorous understanding of how multicellular behaviors arise from the actions of single cells
requires quantitative frameworks that bridge the gap between genetic circuits, the …

Collective behavior in cellular populations is coordinated by biochemical signaling networks
within individual cells. Connecting the dynamics of these intracellular networks to the …

Unicellular organisms exhibit elaborate collective behaviors in response to environmental
cues. These behaviors are controlled by complex biochemical networks within individual …

Many biological and physical systems exhibit population-density-dependent transitions to
synchronized oscillations in a process often termed “dynamical quorum sensing” …