Abstract Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding
protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and …

The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …

Abstract Ischemia/reperfusion (I/R) injury is a life-threatening vascular emergency following
myocardial infarction. Our previous study showed cardioprotective effects of metformin …

Lead (Pb) has been concerned as one of the most severe hazardous contaminants,
because it can cause pyroptosis in multiple tissues of mammals and birds. Melatonin (Mel) …

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is featured by intensive
inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis …

Background Silicosis is one of the most common occupational pulmonary fibrosis caused by
respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a …

Corilagin, a gallotannin, shows excellent antioxidant and anti‐inflammatory effects. The
NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation …

NOD‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasome‐
mediated pyroptosis is a crucial event in the preeclamptic pathogenesis, tightly linked with …

Background Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction,
intussusception, acute mesenteric artery embolism, and other diseases and can lead to local …

Sepsis-induced cardiac dysfunction is a leading cause of mortality in intensive care units.
However, the molecular mechanisms underlying septic cardiomyopathy remain elusive …