m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
The role of m6A modification in the biological functions and diseases
X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …
Roles of METTL3 in cancer: mechanisms and therapeutic targeting
C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
The plasticity of mRNA translation during cancer progression and therapy resistance
L Fabbri, A Chakraborty, C Robert, S Vagner - Nature Reviews Cancer, 2021 - nature.com
Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …
N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
The m6A methyltransferase METTL3 promotes LPS-induced microglia inflammation through TRAF6/NF-κB pathway
L Wen, W Sun, D Xia, Y Wang, J Li, S Yang - Neuroreport, 2022 - journals.lww.com
Objectives Microglia are the main effectors in the inflammatory process of the central
nervous system. Once overactivated, microglia may release pro-inflammatory cytokines (IL …
nervous system. Once overactivated, microglia may release pro-inflammatory cytokines (IL …
[PDF][PDF] A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease
H Ramalingam, S Kashyap, P Cobo-Stark, A Flaten… - Cell metabolism, 2021 - cell.com
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder
marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that …
marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that …
[PDF][PDF] RNA m6A modification in cancers: molecular mechanisms and potential clinical applications
N 6-Methyladenosine (m 6 A) RNA modification brings a new dawn for RNA modification
researches in recent years. This posttranscriptional RNA modification is dynamic and …
researches in recent years. This posttranscriptional RNA modification is dynamic and …
The m6A RNA demethylase ALKBH5 promotes radioresistance and invasion capability of glioma stem cells
A Kowalski-Chauvel, MG Lacore, F Arnauduc… - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma stem cells (GBMSCs), which are particularly radio-resistant
and invasive, are responsible for the high recurrence of glioblastoma (GBM). Therefore …
and invasive, are responsible for the high recurrence of glioblastoma (GBM). Therefore …
Characterization of the m6A-associated tumor immune microenvironment in prostate cancer to aid immunotherapy
The aim of this study was to elucidate the correlation between m6A modification and the
tumor immune microenvironment (TIME) in prostate cancer (PCa) and to identify the m6A …
tumor immune microenvironment (TIME) in prostate cancer (PCa) and to identify the m6A …