m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …

The plasticity of mRNA translation during cancer progression and therapy resistance

L Fabbri, A Chakraborty, C Robert, S Vagner - Nature Reviews Cancer, 2021 - nature.com
Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …

The m6A methyltransferase METTL3 promotes LPS-induced microglia inflammation through TRAF6/NF-κB pathway

L Wen, W Sun, D Xia, Y Wang, J Li, S Yang - Neuroreport, 2022 - journals.lww.com
Objectives Microglia are the main effectors in the inflammatory process of the central
nervous system. Once overactivated, microglia may release pro-inflammatory cytokines (IL …

[PDF][PDF] A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease

H Ramalingam, S Kashyap, P Cobo-Stark, A Flaten… - Cell metabolism, 2021 - cell.com
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder
marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that …

[PDF][PDF] RNA m6A modification in cancers: molecular mechanisms and potential clinical applications

C Gu, X Shi, C Dai, F Shen, G Rocco, J Chen, Z Huang… - The innovation, 2020 - cell.com
N 6-Methyladenosine (m 6 A) RNA modification brings a new dawn for RNA modification
researches in recent years. This posttranscriptional RNA modification is dynamic and …

The m6A RNA demethylase ALKBH5 promotes radioresistance and invasion capability of glioma stem cells

A Kowalski-Chauvel, MG Lacore, F Arnauduc… - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma stem cells (GBMSCs), which are particularly radio-resistant
and invasive, are responsible for the high recurrence of glioblastoma (GBM). Therefore …

Characterization of the m6A-associated tumor immune microenvironment in prostate cancer to aid immunotherapy

Z Liu, J Zhong, J Zeng, X Duan, J Lu, X Sun… - Frontiers in …, 2021 - frontiersin.org
The aim of this study was to elucidate the correlation between m6A modification and the
tumor immune microenvironment (TIME) in prostate cancer (PCa) and to identify the m6A …