COPD immunopathology
G Caramori, P Casolari, A Barczyk, AL Durham… - Seminars in …, 2016 - Springer
The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the
innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette …
innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette …
IL-17 cytokines and chronic lung diseases
IL-17 cytokines are expressed by numerous cells (eg, gamma delta (γδ) T, innate lymphoid
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
MA Eskan, R Jotwani, T Abe, J Chmelar, JH Lim… - Nature …, 2012 - nature.com
Aging is linked to greater susceptibility to chronic inflammatory diseases, several of which,
including periodontitis, involve neutrophil-mediated tissue injury. Here we found that aging …
including periodontitis, involve neutrophil-mediated tissue injury. Here we found that aging …
Cytokine production by human neutrophils: Revisiting the “dark side of the moon”
N Tamassia, F Bianchetto‐Aguilera… - European journal of …, 2018 - Wiley Online Library
Polymorphonuclear neutrophils are the most numerous leucocytes present in human blood,
and function as crucial players in innate immune responses. Neutrophils are indispensable …
and function as crucial players in innate immune responses. Neutrophils are indispensable …
Natural history and mechanisms of COPD
P Lange, E Ahmed, ZM Lahmar, FJ Martinez… - …, 2021 - Wiley Online Library
The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …
resulting from numerous interacting factors throughout the life cycle with smoking being the …
Cytokine inhibition in the treatment of COPD
G Caramori, IM Adcock, A Di Stefano… - International journal of …, 2014 - Taylor & Francis
Cytokines play an important part in many pathobiological processes of chronic obstructive
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …
Tertiary lymphoid structure score: a promising approach to refine the TNM staging in resected non-small cell lung cancer
Background We previously proposed an immune cell score (tumour node metastasis (TNM)-
Immune cell score) classifier as an add-on to the existing TNM staging system for non-small …
Immune cell score) classifier as an add-on to the existing TNM staging system for non-small …
The Th17 pathway in cystic fibrosis lung disease
Rationale: Cystic fibrosis (CF) is characterized by bronchoalveolar neutrophilia and
submucosal lymphocytosis. We hypothesized that Th17 lymphocytes are part of this …
submucosal lymphocytosis. We hypothesized that Th17 lymphocytes are part of this …
Targeting cytokines as evolving treatment strategies in chronic inflammatory airway diseases
J Garth, JW Barnes, S Krick - International journal of molecular sciences, 2018 - mdpi.com
Cytokines are key players in the initiation and propagation of inflammation in chronic
inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD) …
inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD) …
An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup
SA Christenson, M Van Den Berge… - The Journal of …, 2019 - Am Soc Clin Investig
BACKGROUND. Chronic obstructive pulmonary disease (COPD) is a heterogeneous
smoking-related disease characterized by airway obstruction and inflammation. This …
smoking-related disease characterized by airway obstruction and inflammation. This …