Dopamine (DA)-containing neurons involved in the regulation of sleep and waking (W) arise
in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNc). The VTA …

Although the neurotransmitter dopamine plays a prominent role in the pathogenesis and
treatment of schizophrenia, the dopamine hypothesis of schizophrenia fails to explain all …

We used intracerebral microdialysis coupled with electrophysiologic recordings to determine
relative changes in the concentrations of several neurotransmitters in the medial prefrontal …

The M5 muscarinic receptor is the most recent member of the muscarinic acetylcholine
receptor family (M1-M5) to be cloned. At present, the physiological relevance of this receptor …

OBJECTIVE: Postmortem studies have implicated the central muscarinic acetylcholine
system in schizophrenia. However, central muscarinic receptor availability has not …

Converging lines of evidence suggest that dysfunction of brain serotonergic systems may
underlie impulsive behavior. However, the nature of this deficit remains poorly understood …

Little is known about the physiological roles of the M5 muscarinic receptor, the last member
of the muscarinic receptor family (M1–M5) to be cloned. In the brain, the M5 receptor …

The release of dopamine in the ventral tegmental area (VTA) plays an important role in the
autoinhibition of the dopamine neurons of the mesocorticolimbic system through the …

Dopamine (DA) and noradrenaline (NA) in the prefrontal cortex (PFC) modulate superior
cognitive functions, and are involved in the aetiology of depressive and psychotic symptoms …

Aims: Concurrent use of ethanol and nicotine (tobacco) is often seen in human beings. In
previous animal experiments, we have demonstrated that nicotinic acetylcholine receptors …