Study on risk factors of diabetic peripheral neuropathy and establishment of a prediction model by machine learning

X Lian, J Qi, M Yuan, X Li, M Wang, G Li, T Yang… - BMC Medical Informatics …, 2023 - Springer
Background Diabetic peripheral neuropathy (DPN) is a common complication of diabetes.
Predicting the risk of developing DPN is important for clinical decision-making and …

History of lower-limb complications and risk of cancer death in people with type 2 diabetes

K Mohammedi, S Harrap, G Mancia, M Marre… - Cardiovascular …, 2021 - Springer
Background Individuals with diabetes and lower-limb complications are at high risk for
cardiovascular and all-cause mortality, but uncertainties remain in terms of cancer-related …

Glyoxalase I is a novel target for the prevention of metabolic derangement

ER Miranda, JM Haus - Pharmacology & Therapeutics, 2023 - Elsevier
Obesity prevalence in the US has nearly tripled since 1975 and a parallel increase in
prevalence of type 2 diabetes (T2D). Obesity promotes a myriad of metabolic derangements …

Recent advances in biomarkers and regenerative medicine for diabetic neuropathy

Y Fujita, T Murakami, A Nakamura - International journal of molecular …, 2021 - mdpi.com
Diabetic neuropathy is one of the most common complications of diabetes. This complication
is peripheral neuropathy with predominant sensory impairment, and its symptoms begin with …

Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes

RB Griggs, DF Santos, DE Laird, S Doolen… - Neurobiology of …, 2019 - Elsevier
Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes.
Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to …

Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy

SA Eid, EL Feldman - Disease Models & Mechanisms, 2021 - journals.biologists.com
Peripheral neuropathy (PN) is a severe complication that affects over 30% of prediabetic
and 60% of type 2 diabetic (T2D) patients. The metabolic syndrome is increasingly …

[HTML][HTML] Issues and challenges in diabetic neuropathy management: a narrative review

CAN Ismail - World Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
Diabetic neuropathy (DN) is a devastating disorder with an increasing prevalence globally.
This epidemic can pose a critical burden on individuals and com-munities, subsequently …

Progressive loss of corneal nerve fibers is associated with physical inactivity and glucose lowering medication associated with weight gain in type 2 diabetes

G Ponirakis, I Al‐Janahi, E Elgassim… - Journal of Diabetes …, 2022 - Wiley Online Library
Abstract Aims/Introduction Limited studies have identified risk factors linked to the
progression of diabetic peripheral neuropathy (DPN) in type 2 diabetes. This study …

Risk-factor trajectories preceding diabetic polyneuropathy: ADDITION-Denmark

ST Andersen, DR Witte, H Andersen, L Bjerg… - Diabetes …, 2018 - Am Diabetes Assoc
OBJECTIVE To study cardiometabolic risk-factor trajectories (in terms of levels and changes
over time) preceding diabetic polyneuropathy (DPN) 13 years after a screen-detected …

Advanced glycation end-products are associated with diabetic neuropathy in young adults with type 1 diabetes

E Al-Saoudi, MMB Christensen, P Nawroth… - Frontiers in …, 2022 - frontiersin.org
Aims/hypothesis Advanced glycation end-products (AGEs) may contribute to the
development of diabetic neuropathy. In young adults with type 1 diabetes, we aimed to …