Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

Here, we provide an update of our review on homeobox genes that we wrote together with
Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have …

Recent genomic studies have identified novel recurrent somatic mutations in patients with
myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic …

Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome,
myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with …

GATA factors are evolutionarily conserved transcription factors that are found in animals,
fungi, and plants. Compared to that of animals, the size of the plant GATA family is …

Background Proteinaceous toxins are observed across all levels of inter-organismal and
intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin …

The polycomb group (PcG) proteins are a large and diverse family that epigenetically
repress the transcription of key developmental genes. They form three broad groups of …

A number of genetic syndromes have been linked to increased risk for Wilms tumor (WT),
hepatoblastoma (HB), and other embryonal tumors. Here, we outline these rare syndromes …

The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid
diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic …

Adenine N6 methylation in DNA (6mA) is widespread among bacteria and phage and is
detected in mammalian genomes, where its function is largely unexplored. Here we show …