Oxidative stress in human pathology and aging: molecular mechanisms and perspectives
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …
[HTML][HTML] Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial
infarction, but morbidity and mortality of acute myocardial infarction are still high …
infarction, but morbidity and mortality of acute myocardial infarction are still high …
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
T Liu, B Xiao, F Xiang, J Tan, Z Chen, X Zhang… - Nature …, 2020 - nature.com
Oxidative stress is associated with many acute and chronic inflammatory diseases, yet
limited treatment is currently available clinically. The development of enzyme-mimicking …
limited treatment is currently available clinically. The development of enzyme-mimicking …
ROS generation and antioxidant defense systems in normal and malignant cells
AV Snezhkina, AV Kudryavtseva… - Oxidative medicine …, 2019 - Wiley Online Library
Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …
in many cellular compartments and play a major role in signaling pathways. Overproduction …
Reactive oxygen species in metabolic and inflammatory signaling
Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …
and pathophysiological signal transduction. Enzymes and subcellular compartments that …
The role of mitochondria in NLRP3 inflammasome activation
Q Liu, D Zhang, D Hu, X Zhou, Y Zhou - Molecular immunology, 2018 - Elsevier
The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …
Proteasomal and autophagic degradation systems
I Dikic - Annual review of biochemistry, 2017 - annualreviews.org
Autophagy and the ubiquitin–proteasome system are the two major quality control pathways
responsible for cellular homeostasis. As such, they provide protection against age …
responsible for cellular homeostasis. As such, they provide protection against age …
Sarcopenia: etiology, nutritional approaches, and miRNAs
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …
Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death
The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …
as they intimately communicate, forming very dynamic platforms termed mitochondria …
The role of mitochondria in inflammation: from cancer to neurodegenerative disorders
The main features that are commonly attributed to mitochondria consist of the regulation of
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …