Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus
(T2DM) remain two major challenges for public health systems globally. In the past 9 years …

The past decade has witnessed a revival of interest in the hormone melatonin, partly
attributable to the discovery that genetic variation in MTNR1B–the melatonin receptor gene …

It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …

The glucagon-like peptide 1 receptor (GLP1R) is a major drug target with several agonists
being prescribed in individuals with type 2 diabetes and obesity,. The impact of genetic …

In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal
protein processing, oxidative stress and proinflammatory cytokines will drive the activation of …

The human MT1 and MT2 melatonin receptors, are G-protein-coupled receptors (GPCRs)
that help to regulate circadian rhythm and sleep patterns. Drug development efforts have …

OBJECTIVE We tested whether the concurrence of food intake and elevated concentrations
of endogenous melatonin, as occurs with late eating, results in impaired glucose control, in …

G protein–coupled receptors (GPCRs) are important therapeutic targets that exhibit
functional selectivity (biased signaling), in which different ligands or receptor variants elicit …

Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an
important modulator of a number of physiological functions. In addition to its rather well …

The presence of signaling-competent G protein-coupled receptors in intracellular
compartments is increasingly recognized. Recently, the presence of G i/o protein-coupled …