The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago during
efforts to optimize methods for the purification of insulin. The hyperglycemic substance was …

Type 2 diabetes is a chronic metabolic disorder that results from defects in both insulin
action and secretion, which is now increasing at pace throughout the world, and its intensity …

Aims To investigate the therapeutic effects and potent mechanism of sinomenine (SIN)
nanoliposomes on nephropathy in diabetic rats. Main methods The protective efficacies of …

Long-term treatment with glucagon-like peptide (GLP)-1 or its analog can improve insulin
sensitivity. However, continuous administration is required due to its short half-life. We …

Alzheimer's disease (AD) is the most common form of dementia. Glucagon-like peptide-1
(GLP-1) gives a new genre in therapeutic targets for intervention in AD with its neurotrophic …

Recent developments indicate that the regeneration of beta cell function and mass in
patients with diabetes is possible. A regenerative approach may represent an alternative …

Introduction Although cost-utility models are frequently used to estimate treatment outcomes
for type 2 diabetes, utilities are not available for key attributes of injectable treatments. The …

Abstract Huang-Lian Jie-Du decoction (HLJDD), a famous traditional Chinese prescription
constituted by Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri and Fructus …

Aims Doxorubicin is a powerful chemotherapeutic agent for cancer, whose use is limited due
to its potential cardiotoxicity. Semaglutide (SEMA), a novel analog of glucagon-like peptide …

Dysregulated glucose metabolism is associated with many chronic diseases such as obesity
and type 2 diabetes mellitus (T2DM), and strategies to restore and maintain glucose …