Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

Highlights•Metabolomics has become a widely applied tool in drug development.•
Metabolomics plays a key role for the identification of physiological response markers.• …

Identification of new drug–target interactions (DTIs) is an important but a time-consuming
and costly step in drug discovery. In recent years, to mitigate these drawbacks, researchers …

Application of materials capable of energy harvesting to increase the efficiency and
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …

Ethnopharmacological relevance Liver fibrosis is a chronic liver disease that can lead to
cirrhosis, liver failure, and hepatocellular carcinoma, and it is associated with long-term …

A plethora of databases exist online that can assist in in silico chemical or drug safety
assessment. However, a systematic review and grouping of databases, based on purpose …

Acyclovir (ACV) is an effective and selective antiviral drug, and the study of its toxicology and
the use of appropriate detection techniques to control its toxicity at safe levels are extremely …

In pharmaceutical research and development, pursuing novel therapeutics and optimizing
existing drugs have been revolutionized by the fusion of cutting-edge technologies and …

Drug discovery is time-consuming, expensive, and predominantly follows the “one drug→
one target→ one disease” paradigm. With the rapid development of systems biology and …

Understanding protein sequence and structure is essential for understanding protein–
protein interactions (PPIs), which are essential for many biological processes and diseases …