Background: Infections caused by multi-drug-resistant Gram-negative bacteria, particularly
Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, that …

Bacterial pneumonia is one of the most serious public health issues owing to its medical and
economic costs, which result in increased morbidity and mortality in people of all ages …

Objectives This study investigated the exposure–response relationships between unbound
colistin in plasma and antibacterial activity in mouse thigh and lung infections. Methods …

Background Nephrotoxicity and neurotoxicity are commonly associated with polymyxin
treatment; however, the emergence of multidrug-resistant Gram-negative bacteria with …

Background Cases of ventilator-associated pneumonia (VAP) due to multidrug-resistant
(MDR) gram-negative bacilli (GNB) mainly Acinetobacter baumannii, Pseudomonas …

Objectives To characterize the antimicrobial susceptibility, molecular epidemiology and
carbapenem resistance mechanisms in Pseudomonas aeruginosa isolates recovered from …

Background The pharmacokinetic/pharmacodynamic (PK/PD) relationship for polymyxin B
against Klebsiella pneumoniae infections is not known. Methods Dose-fractionation studies …

Аннотация Обсуждаются систематические обзоры и метаанализы последних лет,
посвященные пневмонии. Заболеваемость пневмонией в Европе и Северной Америке …

Over the last several decades, antibacterial drug use has become widespread with their
misuse being an ever-increasing phenomenon. Consequently, antibacterial drugs have …

Increasing incidence of resistance of gram-negative bacteria against even newer antibiotic
including carbapenem has generated interest in the old antibiotic colistin, which are being …