This volume covers all aspects of melanin pigmentation, providing a concise,
comprehensive picture of new knowledge gained at the frontiers of research. It draws …

Aloesin,[2‐acetonyl‐8‐β‐d‐glucopyranosyl‐7‐hydroxy‐5‐methylchromone], a compound
isolated from the Aloe plant, is shown in these studies to modulate melanogenesis via …

We previously demonstrated that human keratinocytes produce and secrete endothelins
(ET), which can be strong mitogens for human melanocytes. Ultraviolet B (UVB) exposure …

We demonstrate here that human melanocytes could be regulated by endothelin (ET)
derivatives, potent vasoconstrictive peptides synthesized by endothelial cells, to stimulate …

To understand the signalling mechanisms involved in the dual stimulatory effects of
endothelin-1 (ET-1) on DNA synthesis and melanization in cultured human melanocytes, we …

Cleavage-arrested embryos of the ascidian Ciona intestinalis were able to differentiate two
tissue-specific enzymes—muscle acetylcholinesterase (EC 3.1. 1.7) and brain pigment cell …

Recently we demonstrated that endothelins secreted from human keratinocytes act as
intrinsic mitogens and melanogens for human melanocytes in UVB-induced melanosis. We …

Certain drugs and chemicals, such as chloroquine, chlorpromazine, and 1‐methyl‐4‐phenyl‐
1, 2, 3, 6‐tetrahydropyridine (MPTP), are bound to melanin and retained in pigment cells for …

Taxol, characterized by increased activity in baseline lesions and the appearance of new
lesions, followed by improvement on follow-up scans. Evidence of clinical response (> 50 …

Publisher Summary The bioavailability of molecules exclusively screened through in vitro
assays can be low. In vivo administration is limited to the parenteral route, and their clinical …