The dwindling supply of new antibiotics largely reflects regulatory and commercial
challenges, but also a failure of discovery. In the 1990s the pharmaceutical industry …

For over seven decades, bacteria served as a valuable source of bioactive natural products
some of which were eventually developed into drugs to treat infections, cancer and immune …

Galaxy masses play a fundamental role in our understanding of structure formation models.
This review addresses the variety and reliability of mass estimators that pertain to stars, gas …

Microbial-derived natural products provide the foundation for most of the chemotherapeutic
arsenal available to contemporary medicine. In the face of a dwindling pipeline of new lead …

S treptomyces albus J 1074 is a streptomycete strain widely used as a host for expression of
secondary metabolite gene clusters. Bioinformatic analysis of the genome of this organism …

Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

Rare Actinomycetes from underexplored marine environments are targeted in drug
discovery studies due to the Actinomycetes' potentially huge resource of structurally diverse …

There is an increased need for new drug leads to treat diseases in humans, animals and
plants. A dramatic example is represented by the need for novel and more effective …

Actinomycetes are a rich source of natural products, and these mycelial bacteria produce the
majority of the known antibiotics. The increasing difficulty to find new drugs via high …

Covering: up to 2015 Multienzyme polyketide synthases (PKSs) are molecular-scale
assembly lines which construct complex natural products in bacteria. The underlying …