Covering up to end 2015 Microbial fermentation provides an attractive alternative to
chemical synthesis for the production of structurally complex natural products. In most cases …

Streptomyces are Gram-positive microorganisms able to adapt and respond to different
environmental conditions. It is the largest genus of Actinobacteria comprising over 900 …

Many representatives of the order Actinomycetales are prolific producers of thousands of
biologically active secondary metabolites. Actinomycetes from terrestrial sources have been …

Bacterial natural products have proven to be invaluable starting points in the development of
many currently used therapeutic agents. Unfortunately, traditional culture-based methods for …

Heterologous gene expression is one of the main strategies used to access the full
biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural …

Streptomyces is taken as an important resource for producing the most abundant antibiotics
and other bio-active natural products, which have been widely used in pharmaceutical and …

Bacterially produced secondary metabolites are used as antibiotics, anticancer drugs, and
for many other medicinal applications. The mechanisms that limit the production of these …

Microbial symbiotic communities of marine macro-organisms carry functional metabolic
profiles different to the ones found terrestrially and within surrounding marine environments …

Covering: up to 2015 Over the centuries, microbial secondary metabolites have played a
central role in the treatment of human diseases and have revolutionised the pharmaceutical …

Although natural products have been marginalized by major pharmaceutical companies
over the last 20–30 years, the changing landscape of drug discovery now favors a greatly …