The high-performance liquid chromatography-mass spectrometry (LC-MS) technique is
widely applied to routine analysis in many matrices. Despite the enormous application of …

We are in the midst of a shift in biological research paradigms from reductionist
methodologies that generate a hypothesis and rigorously and quantitatively measure the …

Determining metabolomic differences among samples of different phenotypes is a critical
component of metabolomics research. With the rapid advances in analytical tools such as …

Mass spectrometry (MS) offers unparalleled qualitative and quantitative chemical
information. While increasingly considered a universal detector, the limitations of MS to …

Metabolome analysis is a key component of serum/plasma metabolomics studies for clinical
and biological applications. There are several steps involved, including pre-analytical …

S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced
de novo via the methionine cycle. The demethylation of SAM produces S …

Human exposure to hundreds of chemicals, a primary component of the exposome, has
been associated with many diseases. Urinary biomarkers of these chemicals are commonly …

Chronic obstructive pulmonary disease (COPD) has become the third leading cause of
global death. Insufficiency in early diagnosis and treatment of COPD, especially COPD …

The concentration of thiol and thioether metabolites in plasma has diagnostic value in
genetic diseases of B-vitamin metabolism linked to methionine utilization. Among these …

The metabolome and lipidome are critical components in illustrating biological processes
and pathological mechanisms. Generally, two or more independent methods are required to …