Serine hydrolases (SHs) comprise a large family of hydrolytic enzymes that play crucial roles
in numerous physiological and pathological processes, such as blood coagulation, cancer …

As the most important members of serine esterase hydrolase superfamily, mammalian
carboxylesterases (CESs) are widely distributed in various tissues like liver, intestine, lung …

Remdesivir, an intravenous nucleotide prodrug, has been approved for treating COVID-19 in
hospitalized adults and pediatric patients. Upon administration, remdesivir can be readily …

Abstract Carboxylesterase 2 (CES2) is one of the most important Phase I drug metabolizing
enzymes in the carboxylesterase family. It plays crucial roles in the bioavailability of oral …

Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is
capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and …

Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …

Dipeptidyl peptidase-IV (DPP-IV) plays a critical role in glucose metabolism and has
become an important target for type 2 diabetes mellitus. We previously reported a two …

A mild strategy for visible-light-induced synthesis of bis (indolyl) methanes was developed
using aromatic aldehydes and indole as substrates. This reaction could be performed at …

Abstract Human carboxylesterase 2 (hCES2) is an enzyme that metabolizes irinotecan to SN-
38, a toxic metabolite considered a significant source of side effects (lethal delayed …

Gut bacterial β-glucuronidase (GUS) can reactivate xenobiotics that exert enterohepatic
circulation-triggered gastrointestinal tract toxicity. GUS inhibitors can alleviate drug-induced …