With the aging of the world population, neurodegenerative diseases are considered
crippling diseases, which seriously affect the quality of life and are an increasing burden on …

Background Due to the global increase in aging populations and changes in modern
lifestyles, the prevalence of neurodegenerative diseases, cerebrovascular disorders …

Medicinal plants and herbal extracts from traditional Chinese medicine are used
increasingly commonly worldwide for their benefits to health and quality of life as dietary …

Background: Bupivacaine (BUP) acts as a local anesthetic, which is extensively used for
clinical patients but could generate neurotoxicity in neurons. Tetramethylpyrazine (TET) …

The family of myocyte enhancer factor 2 (MEF2) transcription factors comprises four highly
conserved members that play an important role in the nervous system. They appear in …

In this study, we investigated the cardioprotective mechanisms of action of DT-010, a novel
danshensu-tetramethylpyrazine conjugate. DT-010 significantly preserved cell viability and …

The over-activation of NMDA receptor via the excessive glutamate is believed to one of the
most causal factors associated with Alzheimer's disease (AD), a progressive …

Parkinson's disease (PD) is among the most prevalent neurodegenerative diseases.
Available evidences support the view of PD as a complex disease, being the outcome of …

Objective: To investigate the effect of methylene blue (MB) analogues (2-
Chlorophenothiazine, Neutral red, Azure A and Azure B) on glutamate-induced HT22 …

Accumulating evidence suggests that myocyte enhancer factor 2D (MEF2D) is a pro-survival
factor for neurons. However, whether MEF2D is involved in protecting neurons from cerebral …