Flavonoids in cancer and apoptosis

M Abotaleb, SM Samuel, E Varghese, S Varghese… - Cancers, 2018 - mdpi.com
Cancer is the second leading cause of death globally. Although, there are many different
approaches to cancer treatment, they are often painful due to adverse side effects and are …

The fascinating effects of baicalein on cancer: a review

H Liu, Y Dong, Y Gao, Z Du, Y Wang, P Cheng… - International journal of …, 2016 - mdpi.com
Cancer is one of the leading causes of death worldwide and a major global health problem.
In recent decades, the rates of both mortality and morbidity of cancer have rapidly increased …

[HTML][HTML] An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways

Z Hu, Y Guan, W Hu, Z Xu, M Ishfaq - Iranian Journal of Basic …, 2022 - ncbi.nlm.nih.gov
The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties
and are mainly found in the roots of Oroxylum indicum (L.) Kurz and Scutellaria baicalensis …

Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma

B Bie, J Sun, Y Guo, J Li, W Jiang, J Yang… - Biomedicine & …, 2017 - Elsevier
Abstract Baicalein (5, 6, 7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one) is a flavonoid
compound derived from the roots of Scutellaria baicalensis. It has historically been used in …

Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer

X Pang, X Zhang, Y Jiang, Q Su, Q Li, Z Li - Biomolecules, 2021 - mdpi.com
Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …

Safranal induces DNA double-strand breakage and ER-stress-mediated cell death in hepatocellular carcinoma cells

A Al-Hrout, A Chaiboonchoe, B Khraiwesh, C Murali… - Scientific reports, 2018 - nature.com
Poor prognoses remain the most challenging aspect of hepatocellular carcinoma (HCC)
therapy. Consequently, alternative therapeutics are essential to control HCC. This study …

Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells

TW Kim - Acta Pharmacologica Sinica, 2022 - nature.com
Previous reports suggested that cinnamaldehyde (CA), the bioactive ingredient in
Cinnamomum cassia, can suppress tumor growth, migratory, and invasive abilities …

Phytochemicals as potent modulators of autophagy for cancer therapy

MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

Phytochemicals as a complement to cancer chemotherapy: pharmacological modulation of the autophagy-apoptosis pathway

MA Rahman, MA Hannan, R Dash… - Frontiers in …, 2021 - frontiersin.org
Bioactive plant derived compounds are important for a wide range of therapeutic
applications, and some display promising anticancer properties. Further evidence suggests …

Autophagy: a potential therapeutic target of polyphenols in hepatocellular carcinoma

C Kiruthiga, KP Devi, SM Nabavi, A Bishayee - Cancers, 2020 - mdpi.com
Autophagy is a conserved biological phenomenon that maintains cellular homeostasis
through the clearing of damaged cellular components under cellular stress and offers the …