Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin …
Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
New insights into 5hmC DNA modification: generation, distribution and function
Dynamic DNA modifications, such as methylation/demethylation on cytosine, are major
epigenetic mechanisms to modulate gene expression in both eukaryotes and prokaryotes. In …
epigenetic mechanisms to modulate gene expression in both eukaryotes and prokaryotes. In …
Neuroprotective actions of dietary choline
JK Blusztajn, BE Slack, TJ Mellott - Nutrients, 2017 - mdpi.com
Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (eg,
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …
Advanced cell culture techniques for cancer drug discovery
CJ Lovitt, TB Shelper, VM Avery - Biology, 2014 - mdpi.com
Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
Epigenetics and bacterial infections
Epigenetic mechanisms regulate expression of the genome to generate various cell types
during development or orchestrate cellular responses to external stimuli. Recent studies …
during development or orchestrate cellular responses to external stimuli. Recent studies …
[HTML][HTML] Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
DNA methylation at the 5-position of cytosines (5mC) represents an important epigenetic
modification involved in tissue differentiation and is frequently altered in cancer. Recent …
modification involved in tissue differentiation and is frequently altered in cancer. Recent …
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
Z Chen, F Miao, AD Paterson… - Proceedings of the …, 2016 - National Acad Sciences
We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at
specific loci over two different time points in people with diabetes are associated with …
specific loci over two different time points in people with diabetes are associated with …
Toxicological status of nanoparticles: what we know and what we don't know
The field of nanotechnology has grown exponentially during the last few decades, due in
part to the use of nanoparticles in many manufacturing processes, as well as their potential …
part to the use of nanoparticles in many manufacturing processes, as well as their potential …
Molecular targeting of hypoxia in radiotherapy
Hypoxia (low O 2) is an essential microenvironmental driver of phenotypic diversity in
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …
The dynamics of DNA methylation in schizophrenia and related psychiatric disorders
DR Grayson, A Guidotti - Neuropsychopharmacology, 2013 - nature.com
Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …