Malignant brain tumors are among the most lethal of human tumors, with limited treatment
options currently available. A complex array of recurrent genetic and epigenetic changes …

Human exposure to nanomaterials and nanoparticles is increasing rapidly, but their effects
on human health are still largely unknown. Epigenetic modifications are attracting ever more …

Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …

Asthma is a common complex respiratory disease characterized by chronic airway
inflammation and partially reversible airflow obstruction resulting from genetic and …

The global diversity of fungi has been estimated between 2 to 11 million species, of which
only about 155 000 have been named. Most fungi are invisible to the unaided eye, but they …

Challenging skeletal repairs are frequently seen in patients experiencing systemic
inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we …

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Diabetic vascular
complications such as DN can progress despite subsequent glycemic control, suggesting a …

Epigenetics is emerging as the missing link among genetic inheritance, environmental
influences, and body and brain health status. In the brain, specific changes in nucleic acids …

Detection of epigenetic markers, including 5-methylcytosine, is crucial due to their role in
gene expression regulation and due to the mounting evidence of aberrant DNA methylation …

Background & objectives Hepatocellular carcinoma (HCC) is the second leading cause of
cancer death worldwide. Several types of chronic liver disease predispose to HCC, and …