[HTML][HTML] New insight-guided approaches to detect, cure, prevent and eliminate malaria
S Kumar, R Kumari, R Pandey - Protoplasma, 2015 - Springer
New challenges posed by the development of resistance against artemisinin-based
combination therapies (ACTs) as well as previous first-line therapies, and the continuing …
combination therapies (ACTs) as well as previous first-line therapies, and the continuing …
Chaperonin—Co-chaperonin interactions
A Boshoff - The Networking of Chaperones by Co-chaperones …, 2015 - Springer
Co-chaperonins function together with chaperonins to mediate ATP-dependant protein
folding in a variety of cellular compartments. GroEL and its co-chaperonin GroES are the …
folding in a variety of cellular compartments. GroEL and its co-chaperonin GroES are the …
[HTML][HTML] 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterisation and …
F Mazzone, A Hoeppner, J Reiners… - Biochemical …, 2024 - portlandpress.com
Toxoplasma gondii is a widely distributed apicomplexan parasite causing toxoplasmosis, a
critical health issue for immunocompromised individuals and for congenitally infected …
critical health issue for immunocompromised individuals and for congenitally infected …
Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors
T Bodill, AC Conibear, MKM Mutorwa, JL Goble… - Bioorganic & medicinal …, 2013 - Elsevier
DOXP-reductoisomerase (DXR) is a validated target for the development of antimalarial
drugs to address the increase in resistant strains of Plasmodium falciparum. Series of aryl …
drugs to address the increase in resistant strains of Plasmodium falciparum. Series of aryl …
Targeting plasmodium metabolism to improve antimalarial drug design
C Avitia-Dominguez, E Sierra-Campos… - Current Protein and …, 2016 - ingentaconnect.com
Malaria is one of the main infectious diseases in tropical developing countries and
represents high morbidity and mortality rates nowadays. The principal etiological agent P …
represents high morbidity and mortality rates nowadays. The principal etiological agent P …
[PDF][PDF] Rational design and regioselective synthesis of conformationally restricted furan-derived ligands as potential anti-malarial agents
MK Mutorwa, I Nokalipa, DC Tanner, GL Blatch… - Organic …, 2020 - arkat-usa.org
Substituted 3-furanomethyl phosphate esters and their corresponding phosphoric acids
have been prepared as conformationally restricted analogues of DOXP, the natural …
have been prepared as conformationally restricted analogues of DOXP, the natural …
NOVEL ANTIMALARIAL AGENTS AND TARGETS: AN OPTIMISM OVER RESISTANCE.
P Jain, DS Bele - International Journal of Pharmaceutical …, 2015 - search.ebscohost.com
Malaria is a complex disease with ample of host-parasite interactions. Due to long terminal
elimination half-life, a shallow concentration-effect relationship, and mutations a drug …
elimination half-life, a shallow concentration-effect relationship, and mutations a drug …
Chaperonin: Co-chaperonin Interactions
A Boshoff - The Networking of Chaperones by Co-Chaperones, 2022 - Springer
Co-chaperonins function together with chaperonins to mediate ATP-dependent protein
folding in a variety of cellular compartments. Chaperonins are evolutionarily conserved and …
folding in a variety of cellular compartments. Chaperonins are evolutionarily conserved and …
[PDF][PDF] Modulation of Plasmodium falciparum chaperones PfHsp70-1 and PfHsp70-x by small molecules
IL Cockburn - 2012 - core.ac.uk
The heat shock proteins of~ 70 kDa (Hsp70s) are a conserved group of molecular
chaperones important in maintaining the protein homeostasis in cells, carrying out functions …
chaperones important in maintaining the protein homeostasis in cells, carrying out functions …