New challenges posed by the development of resistance against artemisinin-based
combination therapies (ACTs) as well as previous first-line therapies, and the continuing …

Co-chaperonins function together with chaperonins to mediate ATP-dependant protein
folding in a variety of cellular compartments. GroEL and its co-chaperonin GroES are the …

Toxoplasma gondii is a widely distributed apicomplexan parasite causing toxoplasmosis, a
critical health issue for immunocompromised individuals and for congenitally infected …

DOXP-reductoisomerase (DXR) is a validated target for the development of antimalarial
drugs to address the increase in resistant strains of Plasmodium falciparum. Series of aryl …

Malaria is one of the main infectious diseases in tropical developing countries and
represents high morbidity and mortality rates nowadays. The principal etiological agent P …

Substituted 3-furanomethyl phosphate esters and their corresponding phosphoric acids
have been prepared as conformationally restricted analogues of DOXP, the natural …

Malaria is a complex disease with ample of host-parasite interactions. Due to long terminal
elimination half-life, a shallow concentration-effect relationship, and mutations a drug …

Co-chaperonins function together with chaperonins to mediate ATP-dependent protein
folding in a variety of cellular compartments. Chaperonins are evolutionarily conserved and …

The heat shock proteins of~ 70 kDa (Hsp70s) are a conserved group of molecular
chaperones important in maintaining the protein homeostasis in cells, carrying out functions …