1, 8-Naphthyridine derivatives as cholinesterases inhibitors and cell Ca2+ regulators, a multitarget strategy for Alzheimer's disease
J Egea, C de los Rios - Current Topics in Medicinal Chemistry, 2011 - ingentaconnect.com
The synthesis and the pharmacological evaluation of 1, 8-naphthyridine derivatives and
related compounds as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase …
related compounds as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase …
Tacrine-NO donor and tacrine-ferulic acid hybrid molecules as new anti-Alzheimer agents: hepatotoxicity and influence on the cytochrome P450 system in comparison …
Tacrine (CAS 321-64-2) is a reversible acetylcholine esterase inhibitor that, despite exerting
beneficial effects on Alzheimer's disease (AD), displays marked hepatotoxicity. Searching for …
beneficial effects on Alzheimer's disease (AD), displays marked hepatotoxicity. Searching for …
Multi-target novel neuroprotective compound ITH33/IQM9. 21 inhibits calcium entry, calcium signals and exocytosis
M Maroto, AMG de Diego, E Albiñana… - Cell Calcium, 2011 - Elsevier
Compound ITH33/IQM9. 21 (ITH/IQM) belongs to a new family of l-glutamic acid derivatives
with antioxidant and neuroprotective properties on in vitro and in vivo models of stroke …
with antioxidant and neuroprotective properties on in vitro and in vivo models of stroke …
Research strategies developed for the treatment of alzheimer's disease. Reversible and pseudo-irreversible inhibitors of acetylcholinesterase: Structure-activity …
M Alcolea-Palafox, P Posada-Moreno… - Drug design and …, 2014 - Elsevier
Although several research strategies have been developed in the last decades, the current
therapeutic options for the treatment of Alzheimer's disease are limited to three …
therapeutic options for the treatment of Alzheimer's disease are limited to three …
Synthesis of styryl-linked fused dihydropyridines by catalyst-free multicomponent reactions
Herein, we report a rapid catalyst-free three-component reaction of 2-hydroxy-1, 4-
naphthoquinone, cinnamaldehydes and 3-aminopyrazoles in ethanol medium under reflux …
naphthoquinone, cinnamaldehydes and 3-aminopyrazoles in ethanol medium under reflux …
Synthesis, inhibition effects, molecular docking and theoretical studies as Paraoxonase 1 (PON1) inhibitors of novel 1, 4-dihydropyridine substituted sulfonamide …
Abstract The novel sulfonamide substitute 1, 4-dihydropyridine derivatives were synthesized
by the method of Hantzsch reaction. They have been characterized by FT-IR spectroscopy …
by the method of Hantzsch reaction. They have been characterized by FT-IR spectroscopy …
Investigation of the role of linker moieties in bifunctional tacrine hybrids
TJ Eckroat, KD Green, RA Reed, JJ Bornstein… - Bioorganic & medicinal …, 2013 - Elsevier
Alzheimer's disease (AD) is a complex neurological disorder with multiple inter-connected
factors playing roles in the onset and progression of the disease. One strategy currently …
factors playing roles in the onset and progression of the disease. One strategy currently …
Synthesis of piperidine-4-one Derivative Containing Dipeptide: An Acetyl cholinesterase and β-secretase Inhibitor
P Pavadai, S Ramalingam… - Anti-infective …, 2020 - ingentaconnect.com
Background: With the goal of developing Alzheimer's disease therapeutics, we have
designed and synthesized novel piperidone fused dipeptide (DPPS) derivatives possessing …
designed and synthesized novel piperidone fused dipeptide (DPPS) derivatives possessing …
In vitro studies of a series of synthetic compounds for their anti-acetylcholinesterase activities identified arylpyrano [2, 3-f] coumarins as hit compounds
EF Martin, LAE Pollo, LAL da Silva, MW Biavatti… - Journal of Molecular …, 2022 - Elsevier
Alzheimer's disease is one of the most widespread neurodegenerative diseases in the
world. Until now, the drugs used to control this disease have been developed to target …
world. Until now, the drugs used to control this disease have been developed to target …
Design of new drugs for the treatment of Alzheimer's disease based on tacrine structure
R AN de Aquino, LV Modolo, RB Alves… - Current Drug …, 2013 - ingentaconnect.com
Tacrine was the first drug approved by FDA for the treatment of Alzheimer's disease.
However, its use was restricted in function of side effects observed in some patients …
However, its use was restricted in function of side effects observed in some patients …