Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder. Several hallmarks
such as β-amyloid (Aβ) aggregation underlying amyloid plaque formation, Τ …

Novel multifunctional compounds have been designed, synthesized, and evaluated as
potential drugs for the treatment of Alzheimer's disease (AD). With an l-glutamic moiety as a …

Alzheimer's disease is a neurological disorder, which is the most common form of dementia
affecting mostly elderly people. The number of patients is still rapidly increasing which …

Alzheimer's disease (AD) is the most common form of dementia in elder people,
characterised by a progressive decline in memory as a result of an impairment of cholinergic …

Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal
chemistry. Among all of the heterocyclic scaffolds, 1, 4-Dihydropyridine (1, 4-DHP) is one of …

The 1, 4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and
pharmacological actions. It represents one of the most important groups of calcium-channel …

HIGHLIGHTS Many CNS targets are being explored for multi-target drug design New
databases and cheminformatic methods enable prediction of primary pharmaceutical target …

Tacrine (1) was the first acetylcholinesterase inhibitor (AChEI) introduced in therapy for the
treatment of Alzheimer's disease (AD), but similarly to the most recent approved AChEIs and …

Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by β-
amyloid (Aβ) aggregation, τ-hyperphosphorylation, and loss of cholinergic neurons. The …

A series of 9-N-substituted berberine derivatives were synthesized and biologically
evaluated as antioxidant and inhibitors of acetylcholinesterase (AChE) …