Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel
blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to …

Herein we have reviewed our recent developments for the identification of new tacrine
analogues for Alzheimer's disease (AD) therapy. Tacrine, the first cholinesterase inhibitor …

Current options for Alzheimer's disease (AD) treatment are based on administration of
cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or memantine, acting …

A series of berberine-phenyl-benzoheterocyclic (26–29) and tacrine-phenyl-
benzoheterocyclic hybrids (44–46) were synthesised and evaluated as multifunctional anti …

A multicomponent domino reaction of enaminone, malononitrile, and o‐phthalaldehyde has
been established, providing direct access to novel highly functionalized pentacyclic …

Notwithstanding the functional role that the aggregates of some amyloidogenic proteins can
play in different organisms, protein aggregation plays a pivotal role in the pathogenesis of a …

In this paper a series of new 1, 3, 4-thiadiazole derivatives has been designed, synthesized
and evaluated as the acetyl-and butyrylcholinesterase inhibitors. Some analogues showed …

The review summarizes research into the highly relevant topics of cholinesterase and
amyloid aggregation inhibitors connected to tacrine congeners, both of which are associated …

Herein, we disclose a strategy to realize α, β-difunctionalization and C–N bond cleavage of
saturated amines with benzo [c] isoxazoles via a B (C6F5) 3-catalyzed consecutive …

A novel series of quinoxaline derivatives, as Multi-Target-Directed Ligands (MTDLs) for AD
treatment, were designed by lending the core structural elements required for H3R …