An elegant, atom efficient protocol via a one-pot four-component cyclocondensation reaction
of aromatic aldehydes, malononitrile, acetylenedicarboxylates and arylamines catalyzed by …

Dual-target-directed 1, 3-diphenylurea derivatives were designed by hybridizing BACE 1
inhibitor 1 with metal chelator LR-90. A database consisted of 1, 3-diphenylurea derivatives …

From an in-house library of compounds, five phenothiazines and one dibenzothiadiazepine
were selected to be tested in neuroprotective and cholinergic assays. Three of them, derived …

Polyethylene glycol (PEG) has been found to be an inexpensive, non-toxic and useful
medium for the one pot synthesis of highly functionalized dihydropyridines using …

The reversible inhibition of acetylcholinesterase (AChE) has become a promising target for
the treatment of Alzheimer's disease (AD) which is mainly associated with low in vivo levels …

Alzheimer's Disease (AD) is a single major cause of dementia in middle to old age
individuals involving several different etiopathological mechanisms that are yet to be …

We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-
yl)-3-(dimethylamino) propanamide (1) as an effective neuroprotectant and selective …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is a major
health threat globally. Its prevalence is forecasted to exponentially increase during the next …

A fast and highly efficient copper-catalyzed multicomponent synthesis of 1, 4-
dihydropyridines under microwave irradiation is described. The protocol utilizes mild …

Molecular hybridization is a recent strategy based on the covalent fusion of two or more
pharmacophores to create a single molecule with multiple mechanisms of action, which …