A fast and highly efficient copper-catalyzed multicomponent synthesis of 1, 4-
dihydropyridines under microwave irradiation is described. The protocol utilizes mild …

Molecular hybridization is a recent strategy based on the covalent fusion of two or more
pharmacophores to create a single molecule with multiple mechanisms of action, which …

Notwithstanding the clinical use of tacrine was hampered by severe hepatotoxicity, tacrine
still remains a reference scaffold in the search for new efficient drugs for Alzheimer's disease …

Abstract Novel series of fused 1, 4‐dihydropyridine derivatives were designed and
synthesized. Oxidized to the corresponding pyridines were these dihydropyridines. Both …

Benzothiazepine CGP37157 is widely used as tool to explore the role of mitochondria in cell
Ca2+ handling, by its blocking effect of the mitochondria Na+/Ca2+ exchanger. Recently …

The synthesis and pharmacological evaluation of racemic 14-aryl-10, 11, 12, 14-tetrahydro-
9H-benzo [5, 6] chromeno [2, 3-b] quinolin-13-amines (19–28), prepared by Friedländer …

Several QSAR (Quantitative Structure–Activity Relationships) models for predicting the
inhibitory activity of 404 Acetylcholinesterase inhibitors were developed. The whole dataset …

Published information on heterocyclizations involving acetamidines and acetamidoximes
substituted at the α-position with an electron-withdrawing group is reviewed, where these …

The three-component reaction of 2-hydroxy-1, 4-naphthaquinone, aldehydes, and 6-
aminouracil derivatives in acetic acid/water (1: 1; v/v) under microwave heating conditions …

Alzheimer's disease (AD) is a neurodegenerative disorder that is described by multiple
factors linked with the progression of the disease. The currently approved drugs in the …