The main function of AChE is the hydrolysis of the neurotransmitter acetylcholine (ACh) at
the neuromuscular and in cholinergic brain synapses. In some pathologies, loss of …

An eco-friendly one-pot five-component synthesis of novel 1, 2, 3-triazole-linked
pentasubstituted 1, 4-dihydropyridines under ultrasonic and microwave irradiation in …

Calcium-channel blockers have an important role in the treatment of several cardiovascular
disorders. Derivatives of 1, 4-dihydropyridines are one of the most potent calcium …

In this study, a series of multipotent phenylthiazole–tacrine hybrids (7a–7e, 8, and 9a–9m)
were synthesized and biologically evaluated. Screening results showed that phenylthiazole …

A new efficient synthetic route to unsymmetrically substituted dihydropyridine scaffolds via
dehydrative [4+ 2] cycloaddition of N-tosylated α, β-unsaturated imines with aldehydes has …

Recently developed multi-targeted ligands are novel drug candidates able to interact with
monoamine oxidase A and B; acetylcholinesterase and butyrylcholinesterase; or with …

Rationale The mechanism involved in AD is complex, which has prompted to develop
compounds that could simultaneously interact with several potential targets. Here, we report …

Alzheimer's disease (AD) is the most prevalent among the aging diseases known as
neurodegenerative disorders. Drug design programs over the last two decades were mainly …

In this study we report that amino acridine intermediates 7 and 8 were obtained from the
reduction of nitro acridine derivatives 5 and 6 that were synthesized via the condensation of …

The utilization of virtual compound libraries and virtual screening has become a routine
method in drug discovery and has accelerated the research of pharmacy and translational …