International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British …
Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …
Does beta-lactam pharmacokinetic variability in critically ill patients justify therapeutic drug monitoring? A systematic review
FB Sime, MS Roberts, SL Peake, J Lipman… - Annals of intensive …, 2012 - Springer
The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly
altered due to the dynamic, unpredictable pathophysiological changes that occur in critical …
altered due to the dynamic, unpredictable pathophysiological changes that occur in critical …
[HTML][HTML] Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy
J Mensa, J Barberán, A Soriano, P Llinares… - Revista Española de …, 2018 - ncbi.nlm.nih.gov
Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics,
mainly mediated by the expression of inducible chromosomic β-lactamases and the …
mainly mediated by the expression of inducible chromosomic β-lactamases and the …
Continuous infusion of β-lactam antibiotics in severe infections: a review of its role
JA Roberts, J Paratz, E Paratz, WA Krueger… - International journal of …, 2007 - Elsevier
Continuous infusion of β-lactam antibiotics has been widely promoted to optimise their time-
dependent activity. Increasing evidence is emerging suggesting potential benefits in patient …
dependent activity. Increasing evidence is emerging suggesting potential benefits in patient …
Pharmacokinetics/pharmacodynamics of antibacterials in the Intensive Care Unit: setting appropriate dosing regimens
F Scaglione, L Paraboni - International journal of antimicrobial agents, 2008 - Elsevier
Patients admitted to Intensive Care Units (ICUs) are at very high risk of developing severe
nosocomial infections. Consequently, antimicrobials are among the most important and …
nosocomial infections. Consequently, antimicrobials are among the most important and …
Continuous beta-lactam infusion in critically ill patients: the clinical evidence
MH Abdul-Aziz, JM Dulhunty, R Bellomo… - Annals of Intensive …, 2012 - Springer
There is controversy over whether traditional intermittent bolus dosing or continuous infusion
of beta-lactam antibiotics is preferable in critically ill patients. No significant difference …
of beta-lactam antibiotics is preferable in critically ill patients. No significant difference …
Continuous infusion of beta-lactams
JW Mouton, AA Vinks - Current opinion in critical care, 2007 - journals.lww.com
Killing of bacteria by β-lactam antibiotics is maximal at around four times the minimum
inhibitory concentration in vitro. To ensure an optimal effect when treating severe infections …
inhibitory concentration in vitro. To ensure an optimal effect when treating severe infections …
Impact of bolus dosing versus continuous infusion of piperacillin and tazobactam on the development of antimicrobial resistance in Pseudomonas aeruginosa
TW Felton, J Goodwin, L O'Connor… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Management of nosocomial pneumonia is frequently complicated by bacterial resistance.
Extended infusions of beta-lactams are increasingly being used to improve clinical …
Extended infusions of beta-lactams are increasingly being used to improve clinical …
β‐L actam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: A structured review
MG Sinnollareddy, MS Roberts… - Clinical and …, 2012 - Wiley Online Library
Infections and related sepsis are two of the most prevalent issues in the care of critically ill
patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate …
patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate …
How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?
The pharmacokinetics (PK) of antimicrobial agents administered to critically ill patients
exhibit marked variability. This variability results from pathophysiological changes that occur …
exhibit marked variability. This variability results from pathophysiological changes that occur …