Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm initiated by the presence
of the fusion gene BCR:: ABL1. The development of tyrosine kinase inhibitors (TKIs) highly …

DNA double-strand breaks (DSBs) are among the most serious forms of DNA damage. In
humans, DSBs are repaired mainly by non-homologous end joining (NHEJ) and …

Chronic myeloid leukemia (CML) is a type of blood cancer that is known to affect
hematopoietic stem cells. The presence of the Philadelphia chromosome (Ph+) is the major …

Simple Summary This review discusses the optimal selection of BCR-ABL1 tyrosine kinase
inhibitors (TKIs) as the first-line treatment for newly diagnosed chronic myelogenous …

The liver has a central role in metabolism, therefore, it is susceptible to harmful effects of
ingested medications (drugs, herbs, and nutritional supplements). Drug-induced liver injury …

It is vital for physicians and persons with chronic myeloid leukemia (CML) to accurately
predict the likelihood of achieving a major molecular response (MMR) and a deep molecular …

Simple Summary Chronic myeloid leukemia is a disease diagnosed by the presence of the
Philadelphia chromosome, which leads to the BCR:: ABL fusion oncoprotein and overactive …

Tyrosine kinases inhibitors (TKIs) revolutionized chronic myeloid leukemia (CML) treatment
for many years, prolonging patients' life expectancy to be comparable to age-matched …

Background The direct comparison of molecular responses of front-line imatinib (IM)
monitored at the same laboratory between children and adults with chronic phase (CP) of …

Chronic myeloid leukemia (CML) is rare in children but presents a unique challenge as
recent drug innovations have turned CML into a chronic disease with implications for …