The vitamin D metabolite 1α, 25-dihydroxyvitamin D3 is the natural, high-affinity ligand of the
transcription factor vitamin D receptor (VDR). In many tissues and cell types, VDR binds in a …

A low vitamin D status is associated with an increased risk of various cancers, such as of
colon, breast, prostate and hematological cells. The biologically most active vitamin D …

Vitamin D shows a variety of pleiotropic activities which cannot be fully explained by the
stimulation of classic pathway-and vitamin D receptor (VDR)-dependent transcriptional …

The genomic actions of the vitamin D are mediated via its biologically most potent metabolite
1α, 25‐dihydroxyvitamin D3 (1, 25 (OH) 2D3) and the transcription factor vitamin D receptor …

We tested the hypothesis that 1, 25‐dihydroxyvitamin D3 [1α, 25 (OH) 2D3] has antiaging
effects via upregulating nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2), reducing reactive …

Physical activity, combined with adequate nutrition, is considered a protective factor against
cardiovascular disease, musculoskeletal disorders, and intestinal dysbiosis. Achieving …

Uncontrolled overgrowth of cells, such as in cancer, is an unavoidable risk in life that affects
nearly every second individual in industrialized countries. However, in part this risk can be …

Nutrigenomics attempts to characterize and integrate the relation between dietary molecules
and gene expression on a genome-wide level. One of the biologically active nutritional …

In a society where women often want successful careers and equal opportunities to men, the
early nature of ovarian aging often forces women to make difficult life choices between …

Data were obtained from studies in Australia, Canada, and the United States using
individual cow data from 28,230 Holstein cows to evaluate associations between parity and …