Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

Chronic obstructive pulmonary disease (COPD) is a global health issue with high social and
economic costs. Concomitant chronic cardiac disorders are frequent in patients with COPD …

Background: The morbidity and mortality of patients with functional mitral regurgitation (MR)
remain high, but no pharmacological therapy has been proven effective. The hypothesis of …

Remarkable recent advances have revolutionized the field of heart failure. Survival has
improved among individuals with heart failure and a reduced ejection fraction and for the …

Abstract The PARADIGM-HF (Prospective comparison of ARNi with ACEi to Determine
Impact on Global Mortality and Morbidity in Heart Failure) trial demonstrated that a new …

Aims To examine the rates of all‐cause mortality and heart failure (HF) readmission in
patients hospitalized with decompensated HF according to HF duration–new‐onset HF and …

Cardiovascular diseases are one of the main concerns, nowadays causing a high rate of
mortality in the world. The majority of conventional treatment protects the heart from failure …

Objectives: This study sought to determine the rate of use of target doses of foundational
guideline-directed medical therapy (GDMT) in a contemporary cohort of patients with heart …

Heart failure (HF) is a growing epidemic with high morbidity and mortality at an international
scale. The apelin–APJ receptor pathway has been implicated in HF, making it a promising …

Diuretic resistance is a powerful predictor of adverse outcome in acute heart failure (AHF),
irrespectively of underlying glomerular filtration rate. Metrics of diuretic efficacy such as …