Cellular senescence forms a barrier to tumorigenesis, by inducing cell cycle arrest in
damaged and mutated cells. However, once formed, senescent cells often emit paracrine …

Cellular senescence, a persistent form of cell cycle arrest, has been linked to the formation
of heterochromatic foci, accompanied by additional concentric epigenetic layers. However …

Cells remember their identities, in part, by using epigenetic marks—chemical modifications
placed along the genome. How can mark patterns remain stable over cell generations …

Eukaryotic cells exposed to extreme perturbations of homeostasis, which are relatively rare
in nature, succumb to the unregulated and virtually immediate physical breakdown of their …

HMGA1 is an abundant non-histone chromatin protein that has been implicated in
embryonic development, cancer, and cellular senescence, but its specific role remains …

Oncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor
mechanism associated with premalignancy,. Achieving this phenotype typically requires a …

Senescent cells can influence the function of tissues in which they reside, and their
propensity for disease. A portion of adult human pancreatic beta cells express the …

Much of tumour cell biology and the tumour microenvironment may be normal wound‐
healing responses as a consequence of the disruption of tissue structure. This is why …

Macroautophagy (hereafter referred to as autophagy) degrades a variety of cellular
components. A poorly understood area is autophagic degradation of nuclear substrates, or …

Cellular senescence serves as a powerful tumor suppressing mechanism that inhibits the
proliferation of cancer cells bearing oncogenic mutations at the initial stage of cancer …