The dopamine system is involved in motivation, reward and learning, and dysfunction in this
system has been implicated in several disorders, including Parkinson's disease (PD) and …

Certain neurons in the mammalian brain have long been known to be joined by gap
junctions, which are the most common type of electrical synapse. More recently, cloning of …

We describe a strategy for developing hydrophilic chemical cocktails for tissue delipidation,
decoloring, refractive index (RI) matching, and decalcification, based on comprehensive …

Although the mechanisms underlying the loss of neurons in Parkinson's disease are not well
understood, impaired mitochondrial function and pathological protein aggregation are …

Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …

A wealth of specialized neuroendocrine command systems intercalated within the
hypothalamus control the most fundamental physiological needs in vertebrates …

Neurotransmission at dopaminergic synapses has been studied with techniques that
provide high temporal resolution, but cannot resolve individual synapses. To elucidate the …

Within glomeruli, the initial sites of synaptic integration in the olfactory pathway, olfactory
sensory axons terminate on dendrites of projection and juxtaglomerular (JG) neurons. JG …

Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome and related
autism spectrum disorders. MeCP2 is believed to be required for proper regulation of brain …

The use of Cre-driver rodent lines for targeting ventral tegmental area (VTA) cell types has
generated important and novel insights into how precise neurocircuits regulate physiology …