Vascular dysfunction in Alzheimer's disease: a prelude to the pathological process or a consequence of it?

K Govindpani, LG McNamara, NR Smith… - Journal of clinical …, 2019 - mdpi.com
Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis

A Kontush, MJ Chapman - Pharmacological reviews, 2006 - ASPET
High-density lipoproteins (HDL) possess key atheroprotective biological properties,
including cellular cholesterol efflux capacity, and anti-oxidative and anti-inflammatory …

Crosstalk between long noncoding RNAs and microRNAs in health and disease

AS Bayoumi, A Sayed, Z Broskova, JP Teoh… - International journal of …, 2016 - mdpi.com
Protein-coding genes account for only a small part of the human genome; in fact, the vast
majority of transcripts are comprised of non-coding RNAs (ncRNAs) including long ncRNAs …

Mouse models for atherosclerosis and pharmaceutical modifiers

S Zadelaar, R Kleemann, L Verschuren… - … , and vascular biology, 2007 - Am Heart Assoc
Atherosclerosis is a multifactorial highly-complex disease with numerous etiologies that
work synergistically to promote lesion development. The ability to develop preventive and …

Effects of diet on brain plasticity in animal and human studies: mind the gap

T Murphy, GP Dias, S Thuret - Neural plasticity, 2014 - Wiley Online Library
Dietary interventions have emerged as effective environmental inducers of brain plasticity.
Among these dietary interventions, we here highlight the impact of caloric restriction (CR: a …

Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB–driven inflammation and atherosclerosis

K Li, D Ching, FS Luk, RL Raffai - Circulation research, 2015 - Am Heart Assoc
Rationale: Apolipoprotein E (apoE) exerts anti-inflammatory properties that protect against
atherosclerosis and other inflammatory diseases. However, mechanisms by which apoE …

ApoE expression in macrophages communicates immunometabolic signaling that controls hyperlipidemia‐driven hematopoiesis & inflammation via extracellular …

TA Phu, M Ng, NK Vu, AS Gao… - Journal of Extracellular …, 2023 - Wiley Online Library
While apolipoprotein E (apoE) expression by myeloid cells is recognized to control
inflammation, whether such benefits can be communicated via extracellular vesicles is not …

Large animal models of cardiovascular disease

HG Tsang, NA Rashdan, CBA Whitelaw… - Cell biochemistry …, 2016 - Wiley Online Library
The human cardiovascular system is a complex arrangement of specialized structures with
distinct functions. The molecular landscape, including the genome, transcriptome and …

Roles of coagulation proteases and PARs (protease-activated receptors) in mouse models of inflammatory diseases

JJ Posma, SP Grover, Y Hisada… - … , and vascular biology, 2019 - Am Heart Assoc
Activation of the blood coagulation cascade leads to fibrin deposition and platelet activation
that are required for hemostasis. However, aberrant activation of coagulation can lead to …

[PDF][PDF] Functional benefits of citrus fruits in the management of diabetes

OI Aruoma, B Landes, D Ramful-Baboolall… - Preventive …, 2012 - blog.univ-reunion.fr
Citrus fruits are important fruit tree crops in the world and are among the most consumed
fruits after mangoes, tomatoes and bananas. Citrus fruits (Fig. 1 and Table 1) not only …