Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme

Y Zhao, F Liang, Y Xie, YT Duan… - Journal of the …, 2023 - ACS Publications
Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted
extensive research into its biosynthesis. However, certain critical steps, such as the …

Exploring the evolvability of plant specialized metabolism: uniqueness out of uniformity and uniqueness behind uniformity

E Ono, J Murata - Plant and Cell Physiology, 2023 - academic.oup.com
The huge structural diversity exhibited by plant specialized metabolites has primarily been
considered to result from the catalytic specificity of their biosynthetic enzymes. Accordingly …

Plant terpenoid biosynthetic network and its multiple layers of regulation

ME Bergman, RWJ Kortbeek, M Gutensohn… - Progress in Lipid …, 2024 - Elsevier
Terpenoids constitute one of the largest and most chemically diverse classes of primary and
secondary metabolites in nature with an exceptional breadth of functional roles in plants …

[HTML][HTML] Reconstitution of early paclitaxel biosynthetic network

JCT Liu, R De La Peña, C Tocol, ES Sattely - Nature Communications, 2024 - nature.com
Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades,
a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the …

[HTML][HTML] Microbial fortification of pharmacological metabolites in medicinal plants

X Wu, Y Yang, H Zhang - Computational and Structural Biotechnology …, 2023 - Elsevier
Medicinal plants are rich in secondary metabolites with beneficial pharmacological effects.
The production of plant secondary metabolites is subjected to the influences by …

[HTML][HTML] Comparative transcriptomics of two Salvia subg. Perovskia species contribute towards molecular background of abietane-type diterpenoid biosynthesis

M Bielecka, M Stafiniak, B Pencakowski… - Scientific Reports, 2024 - nature.com
Tanshinones, are a group of diterpenoid red pigments present in Danshen–an important
herbal drug of Traditional Chinese Medicine which is a dried root of Salvia miltiorrhiza …

Complete pathway elucidation and heterologous reconstitution of (+)‐nootkatone biosynthesis from Alpinia oxyphylla

X Deng, Z Ye, J Duan, F Chen, Y Zhi, M Huang… - New …, 2024 - Wiley Online Library
Nootkatone is a natural sesquiterpene ketone widely used in food, cosmetics,
pharmaceuticals, and agriculture. It is also regarded as one of the most valuable terpenes …

[HTML][HTML] Stressing the importance of plant specialized metabolites: omics-based approaches for discovering specialized metabolism in plant stress responses

M Wu, TR Northen, Y Ding - Frontiers in Plant Science, 2023 - frontiersin.org
Plants produce a diverse range of specialized metabolites that play pivotal roles in
mediating environmental interactions and stress adaptation. These unique chemical …

[HTML][HTML] Stressing the importance of plant specialized metabolites: omics-based approaches for discovering specialized metabolism in plant stress responses

M Wu, TR Northen, Y Ding - Frontiers in Plant Science, 2023 - frontiersin.org
Plants produce a diverse range of specialized metabolites that play pivotal roles in
mediating environmental interactions and stress adaptation. These unique chemical …

[HTML][HTML] Genomic analysis based on chromosome-level genome assembly reveals Myrtaceae evolution and terpene biosynthesis of rose myrtle

L Yang, J Jin, S Lyu, F Zhang, P Cao, Q Qin, G Zhang… - BMC genomics, 2024 - Springer
Abstract Background Rose myrtle (Rhodomyrtus tomentosa (Ait.) Hassk), is an evergreen
shrub species belonging to the family Myrtaceae, which is enriched with bioactive volatiles …