Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …

Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium
falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via …

Antimicrobial drug resistance is an urgent problem in the control and treatment of many of
the world's most serious infections, including Plasmodium falciparum malaria, tuberculosis …

Genome‐scale metabolic reconstructions can serve as important tools for hypothesis
generation and high‐throughput data integration. Here, we present a metabolic network …

Malaria remains a significant infectious disease that causes millions of clinical cases and>
800,000 deaths per year. The Malaria Box is a collection of 400 commercially available …

Background The identification of genetic changes that confer drug resistance or other
phenotypic changes in pathogens can help optimize treatment strategies, support the …

Novel antimalarial therapies are urgently needed for the fight against drug-resistant
parasites. The metabolism of malaria parasites in infected cells is an attractive source of …

As resistance to current therapies spreads, novel antimalarials are urgently needed. In this
work, we examine the potential for therapeutic intervention via the targeting of Plasmodium …

Apicomplexan parasites infectious to humans include Plasmodium spp., Babesia spp.,
Toxoplasma gondii, Cryptosporidium spp., Isospora belli and Cyclospora cayetanensis. With …

Malaria continues to be an enormous global health challenge, with millions of new infections
and deaths reported annually. This is partly due to the development of resistance by the …