The neurobiology of itch, which is formally known as pruritus, and its interaction with pain
have been illustrated by the complexity of specific mediators, itch-related neuronal pathways …

Neurones in the trigeminocervical complex are the major relay neurones for nociceptive
afferent input from the meninges and cervical structures; therefore, they are the neural …

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability
worldwide, largely due to pain, the primary symptom of the disease. The pain experience in …

Suffering is a state of mind that is difficult to measure and analyse in human beings and
considerably more so in animals. It is related to the environment in which we live and our …

The ability of cells to detect and transduce mechanical stimuli impinging on them is a
fundamental process that underlies normal cell growth, hearing, balance, touch, and pain …

Breakthrough pain or transient worsening of pain in patients with an ongoing steady pain is
a well known feature in cancer pain patients, but it is also seen in non-malignant pain …

Characteristic symptoms of fibromyalgia syndrome include widespread pain, fatigue, sleep
abnormalities, and distress. Patients with fibromyalgia show psychophysical evidence of …

Normally, an obvious antagonism exists between pain and itch. In normal conditions, painful
stimuli suppress itch sensation, whereas pain killers often generate itch. Although pain and …

Background: Central sensitization for pain is important for patients with chronic pain. The
authors investigated a possible role of central sensitization for itch in patients with chronic …

Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch
evokes severe pain. Here we identify a population of peripheral sensory neurons expressing …