Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling …

X Li, Y Hu, B He, L Li, Y Tian, Y Xiao, H Shang… - European Journal of …, 2023 - Elsevier
A series of ursodeoxycholic acid (UDCA)-cinnamic acid hybrids were designed and
synthesized. The anti-inflammatory activity of these derivatives was screened through …

Dual-target inhibitors based on COX-2: a review from medicinal chemistry perspectives

F Zhang, G Zhu, Y Li, Y Qi, Z Wang… - Future Medicinal …, 2023 - Future Science
Inhibitors of COX-2 constitute a class of anti-inflammatory analgesics, showing potential
against certain types of cancer. However, such inhibitors are associated with cardiovascular …

Synthesis and Medicinal Applications of Fenamic Acid Derivatives

M Sharma, P Prasher - Current Organic Chemistry, 2023 - ingentaconnect.com
Fenamic acid-derived NSAIDs contain N-phenyl anthranilic acid as a pharmacophore with
pKa∼ 4, which is completely ionized at the physiological pH and is mainly excreted in the …

Design, synthesis, and biological evaluation of harmine derivatives as topoisomerase I inhibitors for cancer treatment

YL Guo, JW Yu, Y Cao, KX Cheng, YF Zhang… - European Journal of …, 2024 - Elsevier
A series of β-carboline derivatives were designed and synthesized by introducing the
chalcone moiety into the harmine. The synthesized derivatives were evaluated their anti …

Design and discovery of anthranilamide derivatives as a potential treatment for neurodegenerative disorders via targeting cholinesterases and monoamine oxidases

S Zaib, I Khan, HS Ali, MT Younas, A Ibrar… - International Journal of …, 2024 - Elsevier
Neurodegenerative diseases with progressive cellular loss of the central nervous system
and elusive disease etiology provide a continuous impetus to explore drug discovery …

Piperazine‐and Pyrazole‐Based Heterocyclic Scaffold Derivatives Connected with Urea and Thiourea for anti‐Inflammatory Activity

D Bhargavi, S Konduri, J Prashanth… - …, 2023 - Wiley Online Library
A couple of series of heterocyclic‐based urea and thiourea derivatives, connected with a
hybrid scaffold skeleton containing pyrazole and piperazine ring moieties, were achieved. In …

Design and synthesis of novel 3-amino-5-phenylpyrazole derivatives as tubulin polymerization inhibitors targeting the colchicine-binding site

Y Yang, Y Cao, J Yu, X Yu, Y Guo, F Wang… - European Journal of …, 2024 - Elsevier
As the basic unit of microtubules, tubulin is one of the most important targets in the study of
anticarcinogens. A novel series of 3-amino-5-phenylpyrazole derivatives were designed and …