[HTML][HTML] Curcumol: from plant roots to cancer roots
Natural products, an infinite treasure of bioactive scaffolds, have provided an excellent
reservoir for the discovery of drugs since millennium. These naturally occurring, biologically …
reservoir for the discovery of drugs since millennium. These naturally occurring, biologically …
Everything old is new again: drug repurposing approach for non-small cell lung cancer targeting MAPK signaling pathway
Non-small cell lung cancer (NSCLC) is a prominent subtype of lung carcinoma that accounts
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …
Phase II study of selumetinib in children and young adults with tumors harboring activating mitogen-activated protein kinase pathway genetic alterations: arm E of the …
OS Eckstein, CE Allen, PM Williams… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE The NCI-COG Pediatric MATCH trial assigns patients age 1-21 years with
relapsed or refractory solid tumors, lymphomas, and histiocytic disorders to phase II studies …
relapsed or refractory solid tumors, lymphomas, and histiocytic disorders to phase II studies …
Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology
S Mühleder, M Fernández-Chacón… - Cellular and Molecular …, 2021 - Springer
Therapeutic modulation of vascular cell proliferation and migration is essential for the
effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The …
effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The …
Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies
The mitogen-activated protein kinase (MAPK) pathways are crucial regulators of the cellular
processes that fuel the malignant transformation of normal cells. The molecular aberrations …
processes that fuel the malignant transformation of normal cells. The molecular aberrations …
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models
Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer.
Drug development efforts have been focused on kinases in this pathway, most notably on …
Drug development efforts have been focused on kinases in this pathway, most notably on …
Potential anticancer properties and mechanisms of action of formononetin
Nature, a vast reservoir of pharmacologically active molecules, has been most promising
source of drug leads for the cure of various pathological conditions. Formononetin is one of …
source of drug leads for the cure of various pathological conditions. Formononetin is one of …
[HTML][HTML] CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis
The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …
Small-molecule fms-like tyrosine kinase 3 inhibitors: an attractive and efficient method for the treatment of acute myeloid leukemia
Y Zhong, RZ Qiu, SL Sun, C Zhao, TY Fan… - Journal of medicinal …, 2020 - ACS Publications
Fms-like tyrosine kinase 3 (FLT3) is an important member of the class III receptor tyrosine
kinase (RTK) family, which is involved in the proliferation of hematopoietic cells and …
kinase (RTK) family, which is involved in the proliferation of hematopoietic cells and …
Targeted delivery of miRNA based therapeuticals in the clinical management of Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is the most aggressive (WHO grade IV) form of diffuse
glioma endowed with tremendous invasive capacity. The availability of narrow therapeutic …
glioma endowed with tremendous invasive capacity. The availability of narrow therapeutic …