PURPOSE The NCI-COG Pediatric MATCH trial assigns patients age 1-21 years with
relapsed or refractory solid tumors, lymphomas, and histiocytic disorders to phase II studies …

Cell signaling is the process by which extracellular information is transmitted into the cell to
perform useful biological functions. The ERK (extracellular-signal-regulated kinase) …

Background Osteoarthritis (OA) and rheumatoid arthritis (RA) are common joint disorders
that are considered to be different diseases due to their unique molecular mechanisms and …

Cellular signaling pathways involved in the maintenance of the equilibrium between cell
proliferation and apoptosis have emerged as rational targets that can be exploited in the …

Nerium oleander, a member of family Apocynaceae, is commonly known as Kaner in various
countries of Asia and Mediterranean region. This plant has been renowned to possess …

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream
of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that …

Molecular targeted therapy has revolutionized the landscape of cancer treatment due to
better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a …

Cancer is the second leading cause of deaths worldwide. Despite concerted efforts to
improve the current therapies, the prognosis of cancer remains dismal. Highly selective or …

Cognitive impairment in the elderly features complex molecular pathophysiology extending
beyond the hallmark pathologies of traditional disease classification. Molecular subtyping …

Medicinal plants are a vital source of natural products (NPs) that can cure cancer through
modulation of different pathways, including oxidative stress, extrinsic and intrinsic apoptosis …