[HTML][HTML] Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update
Ocular drug delivery is one of the most challenging endeavors among the various available
drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic …
drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic …
[HTML][HTML] Topical drug delivery to the posterior segment of the eye
M Loescher, C Seiz, J Hurst, S Schnichels - Pharmaceutics, 2022 - mdpi.com
Topical drug delivery to the posterior segment of the eye is a very complex challenge.
However, topical delivery is highly desired, to achieve an easy-to-use treatment option for …
However, topical delivery is highly desired, to achieve an easy-to-use treatment option for …
[HTML][HTML] Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future
Background Neurological and ophthalmological neurodegenerative diseases in large part
share underlying biology and pathophysiology. Despite extensive preclinical research on …
share underlying biology and pathophysiology. Despite extensive preclinical research on …
[HTML][HTML] The potential for mitochondrial therapeutics in the treatment of primary open-angle glaucoma: a review
G Kuang, M Halimitabrizi, AA Edziah, R Salowe… - Frontiers in …, 2023 - frontiersin.org
Glaucoma, an age-related neurodegenerative disease, is characterized by the death of
retinal ganglion cells (RGCs) and the corresponding loss of visual fields. This disease is the …
retinal ganglion cells (RGCs) and the corresponding loss of visual fields. This disease is the …
FP and EP2 prostanoid receptor agonist drugs and aqueous humor outflow devices for treating ocular hypertension and glaucoma
NA Sharif, N Odani-Kawabata, F Lu… - Experimental Eye …, 2023 - Elsevier
Prostaglandin (PG) receptors represent important druggable targets due to the many diverse
actions of PGs in the body. From an ocular perspective, the discovery, development, and …
actions of PGs in the body. From an ocular perspective, the discovery, development, and …
Electrical, electromagnetic, ultrasound wave therapies, and electronic implants for neuronal rejuvenation, neuroprotection, axonal regeneration, and IOP reduction
NA Sharif - Journal of Ocular Pharmacology and Therapeutics, 2023 - liebertpub.com
The peripheral nervous system (PNS) of mammals and nervous systems of lower organisms
possess significant regenerative potential. In contrast, although neural plasticity can provide …
possess significant regenerative potential. In contrast, although neural plasticity can provide …
Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery …
Recently, various novel drug delivery systems have been developed to overcome ocular
barriers in order to improve drug efficacy. We have previously reported that montmorillonite …
barriers in order to improve drug efficacy. We have previously reported that montmorillonite …
Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment and prevent …
NA Sharif - Experimental eye research, 2023 - Elsevier
A multitude of pharmacological compounds have been shown to lower and control
intraocular pressure (IOP) in numerous species of animals and human subjects after topical …
intraocular pressure (IOP) in numerous species of animals and human subjects after topical …
Gene therapies and gene product-based drug candidates for normalizing and preserving tissue functions in animal models of ocular hypertension and glaucoma
NA Sharif - Molecular Aspects of Medicine, 2023 - Elsevier
More than 76 million people worldwide are afflicted with the neurodegenerative eye
diseases described and grouped together as glaucoma. A common feature amongst the …
diseases described and grouped together as glaucoma. A common feature amongst the …
PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: cell and nuclear effects
NA Sharif - Biofactors, 2022 - Wiley Online Library
Ocular allergies are becoming more prevalent as more airborne pollutants, irritants and
microbes pervade our environment. Inflammatory and allergic mediators released by …
microbes pervade our environment. Inflammatory and allergic mediators released by …