Breast cancer is the most frequent type of nonskin malignancy among women worldwide. In
general, conventional cancer treatment options (ie, surgery, radiotherapy, chemotherapy …

Folate (vitamin B9) is found in some water-soluble foods or as a synthetic form of folic acid
and is involved in many essential biochemical processes. Dietary folate is converted into …

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in breast
cancer: a Sardinian preliminary case-control study - PMC Back to Top Skip to main content NIH …

There are several evidences supporting the role of 5–10 methylenetetrahydrofolate
reductase (MTHFR) gene polymorphisms in breast cancer (BC). Case control association …

Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that
participate in folate metabolism can be associated with several types of malignant …

We performed a case-control study to investigate the association between single nucleotide
polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This …

Single-nucleotide polymorphisms (SNPs) in one-carbon metabolism genes and lifestyle
factors (alcohol drinking and breast folate) may be determinants of whole-genome …

Aberrations in one-carbon metabolism were reported to increase breast cancer risk by
influencing the DNA synthesis and methylation of DNA and catecholamines. However, the …

Breast cancer is one of the most common malignancies in women worldwide and is
associated with a variety of risk factors. Folate and vitamin B12 are key elements of the one …

Background Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate
metabolism is involved in DNA synthesis, DNA repair and DNA methylation. The functional …