NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Oxidative stress in type 2 diabetes: impacts from pathogenesis to lifestyle modifications

A Caturano, M D'Angelo, A Mormone, V Russo… - Current Issues in …, 2023 - mdpi.com
Oxidative stress is a critical factor in the pathogenesis and progression of diabetes and its
associated complications. The imbalance between reactive oxygen species (ROS) …

[HTML][HTML] Mitochondrial sirtuins, metabolism, and aging

Z Ji, GH Liu, J Qu - Journal of Genetics and Genomics, 2022 - Elsevier
Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Mitochondrial-targeted therapy for doxorubicin-induced cardiotoxicity

BB Wu, KT Leung, ENY Poon - International journal of molecular sciences, 2022 - mdpi.com
Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …

Role of oxidative damage in alzheimer's disease and neurodegeneration: From pathogenic mechanisms to biomarker discovery

FR Buccellato, M D'Anca, C Fenoglio, E Scarpini… - Antioxidants, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder accounting for over 50% of all
dementia patients and representing a leading cause of death worldwide for the global …

[HTML][HTML] Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

V Kumar, S Kundu, A Singh, S Singh - Current neuropharmacology, 2022 - ncbi.nlm.nih.gov
Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3

Q Zhang, J Ren, F Wang, M Pan, L Cui, M Li… - Free Radical Biology and …, 2022 - Elsevier
Mitochondrial function and glucose metabolism play important roles in bidirectional
signaling between granulosa cells (GCs) and oocytes. However, the factors associated with …

The role of SIRT3 in exercise and aging

L Zhou, R Pinho, Y Gu, Z Radak - Cells, 2022 - mdpi.com
The health benefits of regular exercise are well established. Nonetheless, the molecular
mechanism (s) responsible for exercise-induced health benefits remain a topic of debate …

Exosomes derived from adipose mesenchymal stem cells promote diabetic chronic wound healing through SIRT3/SOD2

Y Zhang, X Bai, K Shen, L Luo, M Zhao, C Xu, Y Jia… - Cells, 2022 - mdpi.com
Chronic wounds resulting from diabetes are a major health concern in both industrialized
and developing countries, representing one of the leading causes of disability and death …

Mitochondrial dysfunction and therapeutic perspectives in cardiovascular diseases

Y Liu, Y Huang, C Xu, P An, Y Luo, L Jiao… - International journal of …, 2022 - mdpi.com
High mortality rates due to cardiovascular diseases (CVDs) have attracted worldwide
attention. It has been reported that mitochondrial dysfunction is one of the most important …